Interactive three-dimensional visualization of the results is available at Introductionīipolar disorder (BD) is a severe chronic mental illness that affects ~1% of the general population. These brain abnormalities could represent a biomarker for use in the diagnosis of BD. We demonstrated widespread WM abnormalities in BD and highlighted that altered WM connectivity within the corpus callosum and the cingulum are strongly associated with BD. Results of the meta-analysis showed similar effects. Lithium medication, later onset and short disease duration were related to higher FA along multiple ROIs. Mega-analysis revealed significantly lower FA in patients with BD compared with HC in 29 regions, with the highest effect sizes observed within the corpus callosum ( R 2 = 0.041, P corr < 0.001) and cingulum (right: R 2 = 0.041, left: R 2 = 0.040, P corr < 0.001).
Mean fractional anisotropy (FA) from 43 regions of interest (ROI) and average whole-brain FA were entered into univariate mega- and meta-analyses to differentiate patients with BD from HC. We gathered individual tensor-derived regional metrics from 26 cohorts leading to a sample size of N = 3033 (1482 BD and 1551 HC). This study aimed to identify WM abnormalities that differentiate patients with BD from healthy controls (HC) in the largest DTI dataset of patients with BD to date, collected via the ENIGMA network. Zanetti, 18, 19, 49 Marion Leboyer, 1, 50, 51 Jean-François Mangin, 1 Chantal Henry, 52 Edouard Duchesnay, 1 Josselin Houenou, 1, 2, 50, 51 and for the ENIGMA Bipolar Disorder Working Groupįronto-limbic white matter (WM) abnormalities are assumed to lie at the heart of the pathophysiology of bipolar disorder (BD) however, diffusion tensor imaging (DTI) studies have reported heterogeneous results and it is not clear how the clinical heterogeneity is related to the observed differences. Thompson, 23 Norma Verdolini, 27, 28, 48 Eduard Vieta, 28, 48 Michele Wessa, 34 Heather C. Rosa, 19, 20 Raymond Salvador, 28, 29 Salvador Sarró, 28, 29 Peter R. Mitchell, 38, 39 Mircea Polosan, 40 Edith Pomarol-Clotet, 27, 28 Jonathan Repple, 16 Gloria Roberts, 38, 39 Annerine Roos, 41 Pedro G. Linke, 34, 35 Andrew McIntosh, 33, 36 Elisa M. Howells, 30, 31 Neda Jahanshad, 22 Harald Kugel, 32 Trine V. Foley, 29 Dominik Grotegerd, 16 Tomas Hajek, 8 Unn K. Eyler, 25, 26 Mar Fatjo-Vilas, 27, 28 Sonya F. Ching, 22, 23 Udo Dannlowski, 16 Michael Deppe, 24 Lisa T. Canales-Rodríguez, 11 Xavier Caseras, 21 Tiffany Moukbel Chaim-Avancini, 19, 20 Christopher R. Baune, 15, 16 Francesco Benedetti, 17, 18 Geraldo F. Pauline Favre, 1, 2 Melissa Pauling, 1, 2 Jacques Stout, 1 Franz Hozer, 1, 2, 3, 4 Samuel Sarrazin, 1, 2, 5, 6 Christoph Abé, 7 Martin Alda, 8 Clara Alloza, 9, 10 Silvia Alonso-Lana, 11, 12 Ole A.
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